KMID : 0870519970010010140
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Journal of Korean Academy of Addiction Psychiatry 1997 Volume.1 No. 1 p.140 ~ p.145
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Antianxiety and Antidepressant Effects of Tofisopam in Anxiety Neurosis and Alcohol Abuse or Dependence
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Kim Seung-Tai
Hong Kyung-Sue Kim Doh-Kwan Hong Sung-Do Yu Bum-Hee
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Abstract
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The study aims at evaluating antianxiety and antidepressant effects of tofisopam, a benzodiazepine-related chemical substance with some variations in its nitrogen number and positions. The study subjects were 27 adult outpatients, namely, 11 anxiety neurosis patients(M 6, F 5) and 16 alcohol abuse or alcohol dependence patients(M 13, F 3), diagnosed according to DSM-IV. Tofisopam, doses ranging 100-150mg per day, was administered to each patient in an open clinical trial, over a period of 6-8 week. Each patient was administered with Hamilton Anxiety Scale (HAS) and Hamilton Depression Scale(HDS) twice, before the initiation of tofisopam admininistration and at the completion of 6-8 weeks of the medication administration, to assess the degree and extent of improvements of anxiety and depression
symptoms. The following results were obtained from the study£º (1) Tofisopam showed noticeably significant antianxiety
effects and less significant antidepressant effects. (2) There were no clinically observable or reported untoward
CNS effects(e.g. drowsiness, impaired memory, disturbance in attention, etc.) by tofisopam. (3) The more significant improvements among the anxiety symptom clusters were physical(musculomotor and sensory) and autonomic nervous system symptoms. (4) During and immediately after the completion of 6-8 weeks of tofisopam adminstration, alcoholic patients reported of significantly reduced or extinct alcohol cravings. However, it remains to be carefully evaluated whether anticraving effects of tofisopam is transient, long lasting, or psychogenic, etc. The study results warrants further careful revalidations by use of a longitudinal double-blind crossover design and on a large number of patients.
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KEYWORD
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Tofisopam, Alcohol abuse, Alcohol dependence, Anxiety neurosis
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